A systematic review and meta-analysis by Yang and colleagues, published in JAMA Open Network in October 2021, found that 5-HT1F receptor agonists or “ditans” (lasmiditan) and calcitonin gene-related peptide antagonists or “gepants” (rimegepant and ubrogepant) were not as effective in reducing pain 2 hours post-dose as compared to triptans.
Clarissa Chan, PharmD