This year's recipients of the Lasker Awards, one of the highest honors in medical research, include three scientists whose worked helped transform treatments for hepatitis C virus (HCV). The 2016 Lasker-DeBakey Clinical Medical Research Award was given to Michael J. Sofia, chief scientific officer at Arbutus Biopharma and the lead inventor of the drug sofosbuvir; Ralf F.W. Bartenschlager, head of the department of molecular virology at the University of Heidelberg in Germany; and Charles M. Rice, professor in virology at the Rockefeller University in New York. The researchers were recognized for developing methods of growing HCV in a laboratory setting. Meanwhile, this year's Albert Lasker Basic Medical Research Award will go to three scientists who discovered the way that cells from humans and other animals adapt to changes in the availability of oxygen, while a biochemist at the University of California will receive the Lasker-Koshland Special Achievement Award for his discoveries in DNA replication and protein biochemistry and his leadership of scientific organizations. All of the winners will receive the awards on September 23 in New York.