A self-assessment tool for antithrombotic therapy has been updated by the Institute for Safe Medication Practices (ISMP) to include newer oral anticoagulants. The tool also addresses current strategies for the use of antithrombotic agents, many of which are on ISMP's list of high-alert medications. The goal of the 2017 ISMP Medication Safety Self Assessment for Antithrombotic Therapy is to help health care organizations evaluate their current systems related to the use of antithrombotic agents, proactively identify potential improvement areas, and track their efforts over time. ISMP recommends that health care organizations establish multidisciplinary teams to investigate and document the level of implementation of each self-assessment item, and then reassess their use of antithrombotic agents with the tool on a regular basis. The assessment covers key areas that significantly impact the safe use of antithrombotics, including patient information, drug information, and communication of drug orders and other drug information. Information entered can be saved and returned to at a later time. When the self-assessment is completed, health care organizations can generate a report showing how they scored in each key area as a percentage of the maximum possible score to identify and prioritize opportunities for improvement.