Study: Zinc, folic acid supplement does not improve male fertility

The results of a new study do not support the use of folic acid and zinc supplementation by male partners in the treatment of infertility. The Folic Acid and Zinc Supplementation Trial included 2,370 couples planning infertility treatment.

The results of a new study do not support the use of folic acid and zinc supplementation by male partners in the treatment of infertility. The Folic Acid and Zinc Supplementation Trial included 2,370 couples planning infertility treatment. Male participants were block randomized by study center and planned infertility treatment to receive either folic acid 5 mg and elemental zinc 30 mg or placebo for 6 months. According to the data, however, the couples' live birth rates were not significantly different between the treatment groups, with a rate of 34% in the supplementation group and 35% in the placebo group. Semen quality measured 6 months also did not vary significantly between the two groups. Gastrointestinal symptoms—such as abdominal discomfort or pain and nausea—were more common in the supplementation group compared with the placebo recipients.