Ketofol an alternative deep sedative for EDs

A large study out of Australia has identified an alternative deep sedative appropriate for use in the emergency department (ED). Ketofol, a combination of propofol and ketamine, was shown to be equally effective as propofol alone in this setting.

A large study out of Australia has identified an alternative deep sedative appropriate for use in the emergency department (ED). Ketofol, a combination of propofol and ketamine, was shown to be equally effective as propofol alone in this setting. Anthony Bell, MD, co-lead on the trial, said EDs have tended to shy away from the approach because of concerns about adverse psychological reactions. The new findings, however, showed that study participants randomized to receive ketofol experienced similar outcomes as those who received propofol. The research "will give us more sedation options in the future," Bell remarked, "especially considering the pain relieving properties of ketamine, which may reduce the need for other opiate type medications." The trial, conducted at three Australian hospitals, was reported in the Annals of Emergency Medicine.