Efficacy and safety of a fatty acid amide hydrolase inhibitor in the treatment of cannabis withdrawal and dependence in men

New results from a randomized trial suggest that an experimental drug might help ease withdrawal symptoms in men with cannabis use disorder—but experts caution more research is needed. People with cannabis use disorder can experience cravings, withdrawal, and other issues.

New results from a randomized trial suggest that an experimental drug might help ease withdrawal symptoms in men with cannabis use disorder—but experts caution more research is needed. People with cannabis use disorder can experience cravings, withdrawal, and other issues. Researchers tested the efficacy and safety of the FAAH-inhibitor PF-04457845 in reduction of cannabis withdrawal and cannabis use in men who were daily cannabis users. In a study of 70 men, those who received the drug had fewer withdrawal symptoms and used less marijuana after 4 weeks than men on a placebo. The researchers concluded that PF-04457845, a novel FAAH inhibitor, reduced cannabis withdrawal symptoms and cannabis use in men, and might represent an effective and safe approach for the treatment of cannabis use disorder.