Effectiveness of live attenuated vs. inactivated vaccines in children in Alberta, Canada

With evidence to date failing to provide conclusive answers, a study by the Canadian Immunization Research Network investigated how live attenuated influenza vaccine (LAIV) compares with inactivated influenza vaccine (IIV) in terms of efficacy.

With evidence to date failing to provide conclusive answers, a study by the Canadian Immunization Research Network investigated how live attenuated influenza vaccine (LAIV) compares with inactivated influenza vaccine (IIV) in terms of efficacy. The study focused on the province of Alberta and included data on a total of more than 10,000 patients aged 2–17 years during four influenza cycles. Between 2012–16, more than 3,100 of the children and teens in the sample population tested positive for the virus. Researchers found, however, that patients immunized with LAIV were no more likely to receive a positive test result for laboratory-confirmed influenza than were youth immunized with IIV. The one exception was influenza B during the 2015–16 season, for which LAIV offered greater protection than IIV. Based on the findings, it appears that either vaccination option is appropriate for children and adolescents.