Dressing hastens neuroischemic diabetic foot ulcer healing

New research indicates that sucrose octasulfate dressing could potentially serve as an option for treating neuroischemic diabetic foot ulcers.

New research indicates that sucrose octasulfate dressing could potentially serve as an option for treating neuroischemic diabetic foot ulcers. Results from a randomized, controlled, double-blinded, 20-week trial are published online in <i>Lancet Diabetes & Endocrinology</i> by Michael Edmonds, MD, of the King's College Hospital Diabetic Foot Clinic, London and colleagues. The potassium salt of sucrose octasulfate acts at the tissue level to inhibit excess matrix metalloproteinases while also restoring growth factor function and tissue formation. In the study, which compared sucrose octasulfate to placebo dressing in 240 patients with neuroischemic diabetic foot ulcers, wound healing was significantly improved among patients given the active dressing. The study was conducted in 43 hospitals with specialty diabetes foot clinics in France, Spain, Italy, Germany, and the United Kingdom. Between March 2013 and March 2016, a total of 126 patients with noninfected neuroischemic diabetic foot ulcers greater than 1 cm2 were randomized to sucrose octasulfate dressing and 114 to placebo dressing. Wound closure at week 20&#8212;the primary outcome&#8212;was achieved in 48% of the sucrose octasulfate treatment group compared with 30% of controls, with an adjusted odds ratio of 2.6.