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Understanding the delamination risk of a tri-layer tablet using mini-piloting tools

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A multi-layer tablet is one of the formulation options utilized to mitigate chemical and/or physical incompatibility between different drug substances. Feasibility studies of multi-layer tablets are often conducted using round flat-faced punch tooling. However the link between different tooling designs and multi-layer tablet performance is not well established. This study uses a prototype tri-layer tablet and examines tooling design considerations when conducting small-scale studies to gauge the risk of interfacial defects.
URL: 
http://jpharmsci.org/article/S0022-3549(17)30501-4/fulltext?rss=yes

A multi-layer tablet is one of the formulation options utilized to mitigate chemical and/or physical incompatibility between different drug substances. Feasibility studies of multi-layer tablets are often conducted using round flat-faced punch tooling. However the link between different tooling designs and multi-layer tablet performance is not well established. This study uses a prototype tri-layer tablet and examines tooling design considerations when conducting small-scale studies to gauge the risk of interfacial defects.

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