Acid-suppressive drug use during pregnancy and the risk of childhood asthma

Chinese researchers undertook a systematic review and meta-analysis to examine the relationship between use of acid-suppressive drugs in pregnant women and risk of childhood asthma in their offspring. After searching PubMed, Medline, Embase, the Cochrane Database, and other resources, they pooled eight population-based studies for final analysis.

Chinese researchers undertook a systematic review and meta-analysis to examine the relationship between use of acid-suppressive drugs in pregnant women and risk of childhood asthma in their offspring. After searching PubMed, Medline, Embase, the Cochrane Database, and other resources, they pooled eight population-based studies for final analysis. Based on the evidence, children were indeed more likely to develop asthma if their mothers used proton pump inhibitors or histamine-2 receptor antagonists while carrying them. Although none of the eight studies adjusted for all known confounders in the association between prenatal acid-suppressive drug use and childhood asthma risk, the researchers believe the data can inform care decisions for pregnant women.

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