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CDC names target groups, priorities for novel H1N1 influenza vaccine

Pregnant women top list; elderly patients not included.

Following a special meeting today of the Advisory Committee on Immunization Practices (ACIP), CDC announced a list of five target groups for immunization against the 2009 (novel or pandemic) H1N1 influenza virus:

1. Pregnant women

2. Household contacts of infants younger than 6 months of age

3. Health care workers and emergency medical personnel

4. Children, adolescents, and young adults ages 6 months to 24 years

5. Nonelderly adults with underlying diseases placing them at increased risk of complications from influenza infection

The amount of antigen that will be in the inactivated vaccine will be 15 micrograms (equivalent to the amount of other antigens in seasonal vaccine) and the equivalent amount in the live attenuated vaccine. The ACIP did not include use of an adjuvant in its current recommendations.

Anne Schuchat, MD, Director of CDC’s National Center for Immunization and Respiratory Diseases, told a media briefing that ACIP also addressed the question of prioritization should insufficient supplies of H1N1 vaccine be available initially or if local shortages occur. While downplaying the possibility that prioritization will be necessary, she said that the vaccine should first be used in groups 1 and 2 above, then in the subset of health workers and emergency medical personnel who have direct contact with infected patients or clinical samples, and then in children aged 6 months to 4 years and children and adolescents aged 4 to 18 years with underlying diseases or risk factors.

In response to media questions about the omission of elderly patients from the target lists, Schuchat said that the emphasis in this group should be seasonal influenza vaccination. Thus far, she added, patients older than 65 years have been spared by the 2009 H1N1 influenza virus. Furthermore, once the target groups have been vaccinated against the novel (pandemic) H1N1 influenza strain, other patients, including healthy adults and the elderly, can receive the vaccine as supplies allow. She stressed the importance of individuals getting their seasonal influenza vaccination as soon as vaccine is available.

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L. Michael Posey, BPharm (mposey@aphanet.org)

Posted July 29, 2009; updated 9:00 a.m. July 30, 2009