The Art, Science, and Technology of Pharmaceutical Compounding, 3rd Edition

By Loyd V. Allen, Jr.

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Member Price: $61.95
Non-Member Price: $77.00
ISBN: 978-1-58212-110-9 Publication Date: 2008
Page Count: 556 pages Trim Size: 7” x 10” Binding: Hardcover
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Compounding has always been part of pharmacy practice.  Today it is growing, as pharmacists realize the importance of providing patient-specific products for individualized therapy.  The Art, Science, and Technology of Pharmaceutical Compounding presents in a logical and progressive format all the information that pharmacists and student pharmacists need to understand the purpose and processes of compounding.  Author Loyd V. Allen Jr., the preeminent expert, covers basic guidelines, economic and technical factors that compounding pharmacists must consider, and all aspects of good manufacturing practices for compounded medications.

Key Features:

• The initial chapters describe the requisite facilities and equipment, record keeping, calculations, and quality control.
• The following chapters address the compounding of each dosage form in turn, from powders and granules to injectables.
• Additional chapters cover veterinary compounding, compounding for special populations such as pediatric and geriatric patients, and compounding for specific procedures such as iontophoresis.
• Potential areas of growth are discussed in new chapters on compounding for clinical studies, compounding cosmetics, compounding with hazardous drugs, and compounding in the event of a natural disaster or terrorist attack.
• Nine appendices provide essential information on the compounding process and examples of standard operating procedures.
• The necessary ingredients and steps are listed for compounding more than 200 sample formulations, including bases, vehicles, and ingredient-specific preparations.

Table of Contents:

Preface
Introduction
Abbreviations and Approximate Solubility Descriptors
1.   Guidelines for Compounding Practices
2.   Facilities, Equipment, and Supplies
3.   Records and Record Keeping
4.   Stability of Compounded Preparations
5.   Pharmaceutical Compounding Calculations
6.   Quality Control
7.   Flavors, Sweeteners, and Colors
8.   Preservation, Sterilization, and Depyrogenation
9.   Powders and Granules
10. Capsules
11. Tablets
12. Lozenges/Troches
13. Suppositories and Inserts
14. Sticks
15. Solutions
16. Suspensions
17. Emulsions
18. Ointments, Creams, and Pastes
19. Gels
20. Ophthalmic, Otic, and Nasal Preparations
21. Inhalation Preparations
22. Parenteral Preparations
23. Biotechnology, Nanotechnology, and Pharmacogenomics
24. Special Populations and Preparations
25. Veterinary Pharmaceuticals
26. Compounding for Clinical Studies
27. Cosmetics for Special Populations and for Use as Vehicles
28. Compounding with Hazardous Drugs
29. Compounding for Terrorist Attacks and Natural Disasters

Appendixes
I.    Drugs and Dosage Forms Not to Be Compounded
II.   Standard Operating Procedures
III.  Specific Gravity Values of Selected Liquids
IV.  Using Weight-Related Conversion Factors
V.   Sodium Chloride Equivalent Values of Selected Agents
VI.  Buffers and Buffer Solutions
VII. Allowable Endotoxin Levels in Parenteral Preparations
VIII. Viscosity-Increasing Agents for Aqueous and Nonaqueous Systems
IX.   Disinfecting Agents Used in Compounding Pharmacies

Index

About the Author:

Loyd V. Allen, Jr., PhD, RPh, is Editor-in-Chief of the International Journal of Pharmaceutical Compounding and Professor Emeritus, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma, City Oklahoma. He is author of Allen's Compounded Formulations: The Complete U.S. Pharmacist Collection. He has published hundreds of scientific and professional articles in the pharmacy literature and has trained thousands of pharmacists around the world in good compounding practices.