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Breaking News

APhA DrugInfoLineClinical

›› Immunization responses vary in RA patients treated with rituximab – Treatment with rituximab decreased certain immune system responses and preserved others. These findings may affect timing decisions concerning immunization.
›› Promising oral drugs in the pipeline for relapsing–remitting MS – Results from Phase III studies with oral cladribine and oral fingolimod showed that these novel therapies improved relapse rates and endpoints on MRI in patients with relapsing–remitting MS.
›› Antithrombotic polypharmacy increases bleeding complications after first myocardial infarction – First-time myocardial infarction patients more likely to be readmitted to hospital with bleeding complication when prescribed triple therapy (aspirin, clopidogrel, and vitamin K antagonist) or dual therapy with clopidogrel plus vitamin K antagonist

Pharmacy Today Practice

›› OIG exclusions list: Sounding alarm for awareness – Stiff penalties can threaten affected parties
›› Voltaren Gel: First FDA-approved topical prescription treatment for osteoarthritis – Efficacy and safety of NSAID diclofenac sodium topical gel proven in patients suffering from osteoarthritis pain of the hands and knees.
›› Nilotinib approved for chronic myelogenous leukemia – Approval of nilotinib offers new hope for patients with chronic myeloid leukemia resistant or intolerant to other therapies.

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New Drugs

›› Telavancin (Vibativ—Astellas) – Lipoglycopeptide antibacterial agent for treating adult patients with complicated skin and skin structure infections caused by susceptible gram-positive bacteria
›› Peramivir (BioCryst for CDC) – Neuraminidase inhibitor for treating specific adult and pediatric patients with suspected or laboratory-confirmed H1N1 influenza
›› Asenapine (Saphris—Schering-Plough) – Second-generation antipsychotic used for the acute treatment of schizophrenia and acute treatment of manic and mixed episodes associated with bipolar I disorder in adults
›› Ustekinumab (Stelara—Centocor Ortho Biotech) – Human monoclonal antibody indicated for moderate to severe plaque psoriasis in adult patients
›› Vigabatrin (Sabril—Lundbeck) – Antiepileptic drug indicated as adjunctive therapy (tablet form) for adults with refractory complex partial seizures and as monotherapy (oral solution) for infants 1 month to 2 years of age with infantile spasms

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FDA Watch

›› Risk of PML increases with multiple Tysrabi infusions, FDA says
›› FDA approves first drug to treat Dupuytren's contracture
›› Expanded usage of GSK's Tykerb (lapatinib) and Novartis's Femara (letrozole) for breast cancer approved
›› Rare but serious liver disease reported with Bristol-Myers Squibb's Videx (didanosine) HIV drug
›› Sibutramine levels dangerously high in counterfeit Alli 60-mg capsules

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Educational Resources

ImageNew Product/Therapeutics Bulletins

›› New Therapeutics Bulletin: Ranexa
›› New Product Bulletin: Bystolic
›› New Therapeutics Bulletin: Protonix – Pantoprazole oral suspension is a new dosage form that offers clinicians an additional treatment option for the management of gastroesophageal reflux disease (GERD) and erosive esophagitis. The availability of an alternative dosage form is convenient, and in elderly patients who may have dysphagia or for patients receiving enteral feeding, it offers a clear clinical benefit.

Product Selection Update

›› A Case Study on Pancreatic Enzymes
›› Case Study on Omega-3 Fatty Acids for Treatment of Hypertriglyceridemia

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›› Parkinson’s Disease: Moving Forward With Treatment Modalities – Recent research has elucidated the biologic underpinnings of Parkinson’s disease (PD). It is now clear that PD extends beyond its hallmark motor symptoms, with nonmotor symptoms representing the earliest signs of disease and continuing throughout the disease course. Early recognition and intervention provide an opportunity to maintain maximal function and quality of life. Advances have also been made in the development of treatments for PD and in provision of overall care.
›› COPD: Expanding the Key Role of the Pharmacist
›› Benchmarking in the Treatment of Depression

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›› A Pharmacist’s Guide to Fiber and Digestive Health – Fiber is associated with a number of important health benefits, including normal laxation. Most Americans fall far short of these recommendations. It has been estimated that the average adult consumes only 14 to 15 g of dietary fiber each day.
›› A Pharmacist’s Guide to the Role of Protein in Successful Weight Management – At any given time in the United States, approximately 50% of women and 33% of men are trying to lose weight. Excess weight usually represents an energy imbalance: more calories are being consumed than are being expended in daily activities. People who want to lose weight generally are advised to create an energy deficit of about 500 to 1,000 kcal/day, preferably through a combination of reduced calorie intake and increased physical activity.
›› A Pharmacist’s Guide to Food and Drug Interactions With MAO-B Inhibitors in the Treatment of Parkinson's Disease – Selective monoamine oxidase (MAO)-B inhibitors are useful treatments for Parkinson’s disease (PD). Selegiline and rasagiline are approved as adjuncts to levodopa/carbidopa therapy for patients with PD who exhibit motor fluctuations. Rasagiline is also approved for use as initial monotherapy. Selegiline is available as capsules and orally disintegrating tablets (ODT), and rasagiline is available in tablet form. Pharmacists and their patients should be aware of potential dietary concerns and interactions between MAO-B inhibitors and other medications.