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Breaking News

APhA DrugInfoLineClinical

›› Inhaled corticosteroids: Risks outweigh benefit in COPD – Adding an inhaled corticosteroid to a long-acting beta-2 agonist in patients with COPD has limited benefits
›› HIV vaccine shows a modest benefit in reducing transmission – Administration of four priming injections with ALVAC-HIV and two booster injections of AIDVAX B/E vaccine showed modest results in reducing transmission of HIV-1 infection in low- to moderate-risk heterosexual subjects.
›› Emergency use of peramivir approved – FDA has issued an emergency use authorization for I.V. peramivir for the treatment of specific adult and pediatric patients with suspected or laboratory-confirmed H1N1 influenza.

Pharmacy Today Practice

›› OIG exclusions list: Sounding alarm for awareness – Stiff penalties can threaten affected parties
›› Voltaren Gel: First FDA-approved topical prescription treatment for osteoarthritis – Efficacy and safety of NSAID diclofenac sodium topical gel proven in patients suffering from osteoarthritis pain of the hands and knees.
›› Nilotinib approved for chronic myelogenous leukemia – Approval of nilotinib offers new hope for patients with chronic myeloid leukemia resistant or intolerant to other therapies.

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New Drugs

›› Asenapine (Saphris—Schering-Plough) – Second-generation antipsychotic used for the acute treatment of schizophrenia and acute treatment of manic and mixed episodes associated with bipolar I disorder in adults
›› Ustekinumab (Stelara—Centocor Ortho Biotech) – Human monoclonal antibody indicated for moderate to severe plaque psoriasis in adult patients
›› Vigabatrin (Sabril—Lundbeck) – Antiepileptic drug indicated as adjunctive therapy (tablet form) for adults with refractory complex partial seizures and as monotherapy (oral solution) for infants 1 month to 2 years of age with infantile spasms
›› Prasugrel (Effient—Eli Lilly) – Thienopyridine platelet inhibitor for reducing rate of thrombotic cardiovascular events, including stent thrombosis, in patients with acute coronary syndrome who are to be managed with percutaneous coronary intervention
›› Dronedarone (Multaq—sanofi-aventis) – Antiarrhythmic agent for reducing the risk of cardiovascular hospitalization in patients with paroxysmal or persistent atrial fibrillation (AF) or atrial flutter (AFL) and with a recent episode of AF/AFL and associated cardiovascular risk factors

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FDA Watch

›› Sinex VapoSpray 12-hour Decongestant Ultra Fine Mist Nasal Spray 15 ml (P&G) Lot # 9239028831 recalled, found to to contain gram-negative bacteria Burkholderia cepacia (B. cepacia)
›› Potential foreign particle contamination of Genzyme products
›› FDA warnings of chondrolysis with local anesthetics
›› FDA approves drug treatment for cutaneous T-cell lymphona
›› FDA debuts Safe Use Initiative targeting preventable misuse

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Educational Resources

ImageNew Product/Therapeutics Bulletins

›› New Therapeutics Bulletin: Ranexa
›› New Product Bulletin: Bystolic
›› New Therapeutics Bulletin: Protonix – Pantoprazole oral suspension is a new dosage form that offers clinicians an additional treatment option for the management of gastroesophageal reflux disease (GERD) and erosive esophagitis. The availability of an alternative dosage form is convenient, and in elderly patients who may have dysphagia or for patients receiving enteral feeding, it offers a clear clinical benefit.

Product Selection Update

›› A Case Study on Pancreatic Enzymes
›› Case Study on Omega-3 Fatty Acids for Treatment of Hypertriglyceridemia

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›› Parkinson’s Disease: Moving Forward With Treatment Modalities – Recent research has elucidated the biologic underpinnings of Parkinson’s disease (PD). It is now clear that PD extends beyond its hallmark motor symptoms, with nonmotor symptoms representing the earliest signs of disease and continuing throughout the disease course. Early recognition and intervention provide an opportunity to maintain maximal function and quality of life. Advances have also been made in the development of treatments for PD and in provision of overall care.
›› COPD: Expanding the Key Role of the Pharmacist
›› Benchmarking in the Treatment of Depression

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›› A Pharmacist’s Guide to Fiber and Digestive Health – Fiber is associated with a number of important health benefits, including normal laxation. Most Americans fall far short of these recommendations. It has been estimated that the average adult consumes only 14 to 15 g of dietary fiber each day.
›› A Pharmacist’s Guide to the Role of Protein in Successful Weight Management – At any given time in the United States, approximately 50% of women and 33% of men are trying to lose weight. Excess weight usually represents an energy imbalance: more calories are being consumed than are being expended in daily activities. People who want to lose weight generally are advised to create an energy deficit of about 500 to 1,000 kcal/day, preferably through a combination of reduced calorie intake and increased physical activity.
›› A Pharmacist’s Guide to Food and Drug Interactions With MAO-B Inhibitors in the Treatment of Parkinson's Disease – Selective monoamine oxidase (MAO)-B inhibitors are useful treatments for Parkinson’s disease (PD). Selegiline and rasagiline are approved as adjuncts to levodopa/carbidopa therapy for patients with PD who exhibit motor fluctuations. Rasagiline is also approved for use as initial monotherapy. Selegiline is available as capsules and orally disintegrating tablets (ODT), and rasagiline is available in tablet form. Pharmacists and their patients should be aware of potential dietary concerns and interactions between MAO-B inhibitors and other medications.